Current therapeutic options for Huntington's disease: good clinical practice versus evidence-based approaches?
Identifieur interne : 000613 ( Main/Exploration ); précédent : 000612; suivant : 000614Current therapeutic options for Huntington's disease: good clinical practice versus evidence-based approaches?
Auteurs : Annie Killoran [États-Unis] ; Kevin M. BiglanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Mental Disorders, Movement Disorders.
- therapy : Cognition Disorders, Huntington Disease, Mental Disorders, Movement Disorders.
- Evidence-Based Medicine, Humans.
Abstract
Therapeutic decision-making in Huntington's disease (HD) is often guided by clinical experience, because of the limited empirical evidence available. The only medication for HD that has met the regulatory hurdle for approval is tetrabenazine, indicated for the treatment of chorea. However, its use has limitations, and in the setting of specific contraindications or comorbidities the treatment of choice for chorea is still the multipurpose antipsychotics. For the management of psychiatric disturbances, selective serotonin reuptake inhibitors (SSRIs) and mood stabilizers are often used, although empirical evidence is lacking. Finally, no known effective treatment is available for cognitive dysfunction in HD. We discuss the limited evidence available and current expert opinion on medical treatment of the dominant motor, psychiatric, and cognitive features of HD. This follows a brief introduction on the general principles of HD management and on evidence-based medicine in relation to clinical practice.
DOI: 10.1002/mds.26014
PubMed: 25164707
Affiliations:
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Le document en format XML
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Biglan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25164707</idno><idno type="pmid">25164707</idno><idno type="doi">10.1002/mds.26014</idno><idno type="wicri:Area/PubMed/Corpus">000402</idno><idno type="wicri:Area/PubMed/Curation">000402</idno><idno type="wicri:Area/PubMed/Checkpoint">000629</idno><idno type="wicri:Area/Ncbi/Merge">004101</idno><idno type="wicri:Area/Ncbi/Curation">004101</idno><idno type="wicri:Area/Ncbi/Checkpoint">004101</idno><idno type="wicri:Area/Main/Merge">000613</idno><idno type="wicri:Area/Main/Curation">000613</idno><idno type="wicri:Area/Main/Exploration">000613</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Current therapeutic options for Huntington's disease: good clinical practice versus evidence-based approaches?</title><author><name sortKey="Killoran, Annie" sort="Killoran, Annie" uniqKey="Killoran A" first="Annie" last="Killoran">Annie Killoran</name><affiliation wicri:level="2"><nlm:affiliation>West Virginia University, Morgantown, West Virginia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>West Virginia University, Morgantown, West Virginia</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Biglan, Kevin M" sort="Biglan, Kevin M" uniqKey="Biglan K" first="Kevin M" last="Biglan">Kevin M. Biglan</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (therapy)</term><term>Evidence-Based Medicine</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (therapy)</term><term>Mental Disorders (etiology)</term><term>Mental Disorders (therapy)</term><term>Movement Disorders (etiology)</term><term>Movement Disorders (therapy)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Mental Disorders</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cognition Disorders</term><term>Huntington Disease</term><term>Mental Disorders</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evidence-Based Medicine</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Therapeutic decision-making in Huntington's disease (HD) is often guided by clinical experience, because of the limited empirical evidence available. The only medication for HD that has met the regulatory hurdle for approval is tetrabenazine, indicated for the treatment of chorea. However, its use has limitations, and in the setting of specific contraindications or comorbidities the treatment of choice for chorea is still the multipurpose antipsychotics. For the management of psychiatric disturbances, selective serotonin reuptake inhibitors (SSRIs) and mood stabilizers are often used, although empirical evidence is lacking. Finally, no known effective treatment is available for cognitive dysfunction in HD. We discuss the limited evidence available and current expert opinion on medical treatment of the dominant motor, psychiatric, and cognitive features of HD. This follows a brief introduction on the general principles of HD management and on evidence-based medicine in relation to clinical practice.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie-Occidentale</li></region></list><tree><noCountry><name sortKey="Biglan, Kevin M" sort="Biglan, Kevin M" uniqKey="Biglan K" first="Kevin M" last="Biglan">Kevin M. Biglan</name></noCountry><country name="États-Unis"><region name="Virginie-Occidentale"><name sortKey="Killoran, Annie" sort="Killoran, Annie" uniqKey="Killoran A" first="Annie" last="Killoran">Annie Killoran</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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